PRAGUE, Aug. 11 (Xinhua) -- Czech scientists are examining a new method of fighting against tumor cells, based on a vitamin E analog, which has given promising results when tested on mice, Veronika Kratochvilova from the Biotechnological Institute of the Czech Academy of Sciences (AV) said on Monday.
The vitamin E analog, effective via mitochondria, causes the death of cancer cells without damaging healthy ones, the Czech news agency CTK quoted Kratochvilova as saying.
Tests showed that in the mice, the substance suppresses the emergence of tumors of the large intestine, lungs, pleura, the mammary gland and cervix, she added.
As cancer cells tend to vary and lose sensitivity to the present medicaments, the scientists seek new substances that cancer cells would not resist to and that would not damage healthy cells, according to Kratochvilova.
The scientists said that the effective target for killing tumor cells are mitochondria, small intracellular elements in which cells produce most of the energy they need for their life and growth. Any damaging of mitochondria may kill the respective cell.
The team of Jiri Neuzil, from Prague's Biotechnological Institute, in cooperation with an Australian laboratory, has found out that the vitamin E analog, known as VES, could help in this respect as it affects mitochondria in a way leading to the cell's death.
The scientists have detected the spot in the mitochondria, unknown before, where the anti-cancer intervention is effective. They say this will help develop new, very effective types of medicines against tumor diseases.
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